I just tried installing Dreamweaver MX from CD-ROM with the latest wine from git (wine-1.1.24-292-ga2dd6fb) and it worked fine. Here's what I did: rm -rf ~/.wine (to start with a fresh .wine directory; this deletes anything you had installed before in wine, so don't do this if you aren't sure) cd /media/cdrom/Dreamweaver\ MX wine 'Dreamweaver MX Installer.exe' That's it! No DCOM98, no futzing around. It installed fine (though it warned about needing mdac). To start the app, I had to undo the Z mapping, else it takes forever to start: rm ~/.wine/dosdrives/z: I also installed Fireworks and was able to launch that. Have you tried the simple approach above?