A great way to make duotones includia sepias is Powertone--a program for making 2 color separations--everything's done for you and only needs tweaking for whatever color you want--outputs in 2 or 3 formats. You can try it out for a couple of times via the demo then you have to buy it.
http://www.creo.com/global/products/software_solutions/creative/powertone/default.htm
regards,
joseph
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