I had the same problem with DDO (running on Kubuntu with Audigy2 sound card) after the last update. I found two different solutions: 1) In the wine libraries settings, use native openal32 rather than builtin. Then, some sort of generic playback device appears in the audio settings of DDO. The voice chat does not seem to work, though. 2) Leave openal32 at builtin, and install pulseaudio instead. Then, the full plethora of sound devices (pulseaudio, a bunch of alsa devices and even oss) appears in the audio settings of DDO. The voice chat works in this case, if an appropriate capture device is chosen. I believe the problem is in the interaction between the turbine game engine and wine's openal32. Why the problem is remedied when pulseaudio is installed, is beyond me.
