To make things "easier", of course. Configuring everything about a Wine install through a GUI tends to be so much easier than doing it yourself. However... - These forums (/ this mailing list) are excellent for getting support to get something to run, especially when tricks required for older Wine releases actually break the app in a new version of Wine. Not only that, it leads to bug reports for Wine itself much more quickly than any front-end. - Winetricks already does a good job at the things it supports, and is very minimal. It is very up-to-date because one of the Wine devs actually maintains the project. - Considering what a mess these front-ends make out of things sometimes, using Wine as-is seems like the best solution anyway. Prefixes aren't a difficult concept.