winelib really does not contain any platform particularly stuff to prevent different cpus from being used. The wine loader on the other hand. Highly picky. http://sourceforge.net/projects/hlsl2glsl/ converters exist. Cache would be possible for hlsl stuff. There is a problem of course. Lot of hlsl is not static and is basically altered on fly. Lot of cases if you have the source porting to opengl and not requiring wine should be considered.
