The configuration code solved the problem. Code: [Software\\Wine\\Alsa Driver] "AutoScanCards"="N" "DeviceCount"="1" "DeviceCTL1"="default" "DevicePCM1"="default" "UseDirectHW"="N" Wine is great software. But I really wish information like this was available in documentation, and that winecfg would reply with some useful information when failing. For example "Opening device 'something' failed".