Sometimes Linux cracks me up [Laughing] Just writing this to have it documented in case someone tries to do what I did. I could execute my application and connect flawlessly to the MySQL database via MyODBC/unixODBC. But it turns out if I created a shortcut on the Desktop and tried to run the app from there, it wouldn't connect to the database! It turns out when ran from a shortcut, the exports environment variables are not considered by Gnome! So if you want to create a "shortcut" on your Desktop to run the application on AMD64, you have to actually create a script file instead that looks like this: Code: export LD_LIBRARY_PATH=/usr/lib/odbc/libmysqlclient-i386 export LIB_ODBC_DRIVER_MANAGER=/emul/ia32-linux/usr/lib/libodbc.so.1.0.0 cd /home/username/.wine/drive_c/myapp/ wine myapp.exe And then configure it to run with SH.