Wine can only run EXE files. the VBS file is just a script; Wine wouldn't know what to do with it, so you'll have to find the executable for Windows Scripting Host and run the script with that instead. I'm guessing, however, that WSH "registers" VBS files to WSH so you could use Wine's "start" command to open the VBS file with the appropiate (Windows) program: Code: wine start script.vbs Also, you could have installed WSH a bit easier by using Winetricks, it does all the hard work for you: http://wiki.winehq.org/winetricks