Ok- so I've narrowed it down to the video drivers- because when I boot- I always have to reload proprietary NVidia drivers to get Nuke to run- so I think it's an OPENGL error. Below is *part* of the error I get. Xlib: extension "GLX" missing on display ":0.0". err:wgl:X11DRV_WineGL_InitOpenglInfo couldn't initialize OpenGL, expect problems err:wgl:X11DRV_wglGetProcAddress No libGL on this box - disabling OpenGL support ! err:wgl:X11DRV_wglGetProcAddress No libGL on this box - disabling OpenGL support ! err:wgl:X11DRV_wglGetProcAddress No libGL on this box - disabling OpenGL support ! fixme:wintab32:X11DRV_WTInfoW Return proper size fixme:system:SystemParametersInfoW Unimplemented action: 8202 (SPI_GETFONTSMOOTHINGTYPE) fixme:font:ExtTextOutW flags ETO_NUMERICSLOCAL | ETO_NUMERICSLATIN | ETO_PDY unimplemented ....... *repetitive bits skipped* ...... fixme:font:ExtTextOutW flags ETO_NUMERICSLOCAL | ETO_NUMERICSLATIN | ETO_PDY unimplemented fixme:system:SystemParametersInfoW Unimplemented action: 8202 (SPI_GETFONTSMOOTHINGTYPE) err:wgl:X11DRV_ChoosePixelFormat No libGL on this box - disabling OpenGL support ! err:wgl:X11DRV_SetPixelFormat No libGL on this box - disabling OpenGL support ! err:wgl:X11DRV_wglCreateContext No libGL on this box - disabling OpenGL support ! err:wgl:X11DRV_wglMakeCurrent No libGL on this box - disabling OpenGL support ! wine: Unhandled page fault on read access to 0x00000000 at address (nil) (thread 0009), starting debugger... Unhandled exception: page fault on read access to 0x00000000 in 32-bit code (0x00000000). Register dump: CS:0073 SS:007b DS:007b ES:007b FS:0033 GS:003b EIP:00000000 ESP:0254e54c EBP:0254e568 EFLAGS:00210212( - 00 - RIA1) EAX:00000d56 EBX:7ee75ff4 ECX:0254e5e0 EDX:034ad1a0 ESI:034ad1d8 EDI:034ad1d8 Stack dump: 0x0254e54c: 7ee5bb25 00000d56 0254e580 034ad1d8 0x0254e55c: 034ad1a0 0254e5e0 0254e5e0 00000000 0x0254e56c: 00db4333 00000d56 0254e580 00000000 0x0254e57c: 0254e5e0 00000000 0254e588 00000000 0x0254e58c: 0254e594 00db01c4 00db01cb 291e6c3a 0x0254e59c: 034a7f00 00000000 00000000 00000000 Backtrace: =>1 0x00000000 (0x0254e568) 2 0x00db4333 in nuke5.0 (+0x9b4333) (0x00000000) 0x00000000: addb %al,0x0(%eax) Modules: Module Address Debug info Name (123 modules) PE 230000- 236000 Deferred fncore PE 240000- 298000 Deferred half PE 2a0000- 2d5000 Deferred glew32 PE 3f0000- 3fd000 Deferred _socket.pyd ... and so on. But once I re-enable my video drivers, it works. So again- I believe it's a video driver issue- and not one of WINE. Thanks for your help!