On a hunch, I tried running notepad from that wineprefix, and it too tried unsuccessfully to load the TPkd driver before it started. It seems that PACE Anti-Piracy (which has a whole subfolder, and lots of registry entries) has tainted the entire wineprefix. Can this fairly be called a rootkit? (My other wineprefixes are unaffected. I'm VERY glad I did not install this on Windows.)