Ah, thank you! There is indeed HKEY_LOCAL_MACHINE. Indeed, following that, the error message's suggestion, all the way down to InstallRoot, which still doesn't exist, does (meaning HKEY_LOCAL_MACHINE/Software/Microsoft/.NETFramework does). My first assumption with the information given was that it wants a new key created under .NETFramework, given the name InstallRoot, and directed to ~/.wine/drive_c/windows/Microsoft.NET/Framework (Or Framework/1.1.4322, which is the framework version). However, neither of these appears to have worked, either this way or with backslashes (which I gather is the Windows way of doing things). Any idea what the machine wants done? Thanks in advance!