OK, problem solved. There are a great number of nginx configuration guides that suggest this configuration setting if you're using FastCGI: fastcgi_param PATH_INFO $fastcgi_script_name; Commenting out this setting fixed the problem for me. I'd like to thank Paul Lesniewski for pointing me in the right direction. -- View this message in context: http://squirrelmail.5843.n7.nabble.com/Nginx-Configuration-and-404-Error-tp26248p26254.html Sent from the squirrelmail-users mailing list archive at Nabble.com. ------------------------------------------------------------------------------ Site24x7 APM Insight: Get Deep Visibility into Application Performance APM + Mobile APM + RUM: Monitor 3 App instances at just $35/Month Monitor end-to-end web transactions and take corrective actions now Troubleshoot faster and improve end-user experience. Signup Now! http://pubads.g.doubleclick.net/gampad/clk?id=267308311&iu=/4140 ----- squirrelmail-users mailing list Posting guidelines: http://squirrelmail.org/postingguidelines List address: squirrelmail-users@xxxxxxxxxxxxxxxxxxxxx List archives: http://news.gmane.org/gmane.mail.squirrelmail.user List info (subscribe/unsubscribe/change options): https://lists.sourceforge.net/lists/listinfo/squirrelmail-users