Randy, I doubt if removing the modem will help. I recently had a computer with one built-in serial port and a second serial port on a PCI card such as yours. I wanted to have a refreshable braille display and an external synthesizer on the box, and the only way to get the synthesizer to be recognized was to put it on the built-in port. The braille display worked either way, but the synthesizer only worked on the built-in port. My guess is that without any built-in serial ports, you can forget about installing with speakup. Chuck -- The Moon is Waning Crescent (42% of Full) Only 10 kinds of people: those who do binary, and those who do not. But you can get a few downloads from http://www.mhcable.com/~chuckh