I never tried this since I don't own a serial synthesizer. I recall somebody on this list got Emacspeak to run with their Dectalk Express by running setserial to enable their serial port which Speakup snatches at boot time and masks from the kernel. Of course, you'd want to make sure you had Speakup completely shut down with a printscreen, or it could result in a huge mess. I'd probably go with the software solution just because it's safer, but if you really want the Dectalk Express to work, and aren't afraid to experiment, give it a shot.
