Hi Mark, I am facing a challenge in a setup I must bring up that is composed by a Synopsys Root Complex connected to a MSIx-only Endpoint from Mellanox. The endpoint probe fails because it is not capable of enabling msix. In order to get more info about it, I added some debug messages to the msix enable process and got the following: MSIX DBG[mlx5_enable_msix]: Num. EQs: 256 MSIX DBG[mlx5_enable_msix]: Num. Vectors: 4 MSIX DBG[mlx5_enable_msix]: Min. Num. Vectors: 4 MSIX DBG[mlx5_enable_msix]: Num. Online CPUs: 1 MSIX DBG[mlx5_enable_msix]: MLX5_EQ_VEC_COMP_BASE: 3 MSIX DBG[mlx5_enable_msix]: Filling msix array... entry = 0 MSIX DBG[mlx5_enable_msix]: Filling msix array... entry = 1 MSIX DBG[mlx5_enable_msix]: Filling msix array... entry = 2 MSIX DBG[mlx5_enable_msix]: Filling msix array... entry = 3 MSIX DBG[mlx5_enable_msix]: Enabling PCI MSIX Range MSIX DBG[__pci_enable_msix_range]: Enabling MSIX [Nvec: 4, Affinity: 0] MSIX DBG[__pci_enable_msix]: NVec: 4 MSIX DBG[__pci_enable_msix]: Num. Entries: 64 MSIX DBG[__pci_enable_msix]: Checking invalid entries MSIX DBG[msix_capability_init]: Ensure MSI is disable MSIX DBG[msix_capability_init]: Getting MSIX Capability MSIX DBG[msix_capability_init]: Mapping MSIX Capability Region MSIX DBG[msix_capability_init]: Setup Entries MSIX DBG[msix_setup_entries]: Configuring MSIX entry 0 MSIX DBG[msix_setup_entries]: Configuring MSIX entry 1 MSIX DBG[msix_setup_entries]: Configuring MSIX entry 2 MSIX DBG[msix_setup_entries]: Configuring MSIX entry 3 MSIX DBG[msix_capability_init]: Setup IRQS MSIX DBG[pci_msi_setup_msi_irqs]: Inside! MSIX DBG[arch_setup_msi_irqs]: Inside! MSIX DBG[msix_capability_init]: Failed pci_msi_setup_msi_irqs MSIX DBG[mlx5_enable_msix]: Enabling PCI MSIX Range, result: -22 mlx5_core 0000:01:00.0: enable msix failed The conclusion I came up was that the msix setup in the endpoint fails because in the pcie-designware-host.c we are rejecting msix as you can see here: /* MSI-X interrupts are not supported */ if (type == PCI_CAP_ID_MSIX) return -EINVAL; Did you ever came across this problem? Thanks, Joao