Hi Ede,
Have you tried plugging the device into a different USB port? Sometimes this makes a difference for the USB interrupt.20: <CPU List> IR-IO-APIC 20-fasteoi ohci_hcd:usb9, snd_rme9652, vfio-intx(0000:07:00.0)
So some USB, my passed-through parallel card and my soundcard are all sharing interrupt #20.
And finally you could set the CPU affinity for each interrupt, so at least they're going to be handled by a different CPU than the one that's going to handle the audio interrupt.
Some details about latency tuning, CPU affinities and tuning here:
http://openavproductions.com/real-time-latency-tuning/
Cheers, -Harry
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