Updated gonorrhea treatment guidelines

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Title: Updated gonorrhea treatment guidelines

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Today the U.S. Centers for Disease Control and Prevention published “Update to CDC’s Sexually Transmitted Diseases Treatment 2010 Guidelines:  Oral Cephalosporins No Longer a Recommended Treatment for Gonococcal Infections,” in Morbidity and Mortality Weekly Report

The most significant change to the new guidelines is that CDC no longer recommends an exclusively oral treatment regimen for gonorrhea. CDC now recommends a dual therapy of injectable ceftriaxone in combination with a second antibiotic. Ceftriaxone is more potent against gonorrhea than the once recommended oral antibiotic cefixime and, when paired with the additional oral antibiotic, might slow the emergence of drug resistance by ensuring that gonorrhea infections are quickly cured.

The changes to the gonorrhea treatment guidelines affect how we practice public health.

Please visit the STD Treatment web page  for more information about the treatment changes. A variety of supplemental resources were also developed to accompany the updated guidelines.

Update to CDC's Sexually Transmitted Diseases Treatment 2010 Guidelines: Oral Cephalosporins No Longer a Recommended Treatment for Gonococcal Infections published in the August 10, 2012 issue of MMWR.

  • Audio podcast -- Dr. Robert Kirkcaldy, lead author, discusses updates to CDC's gonorrhea treatment guidelines in this three minute audio podcast.
  • Press Release - Media announcement about updated gonorrhea treatment guidelines, includes quotes from NCHHSTP leadership.
  • Media fact sheet - Details changes to updated gonorrhea treatment, gonorrhea surveillance trends, and a call to action.


U.S. Cephalosporin-Resistant Gonorrhea Response Plan – Offers guidance on steps state and local health departments can take to keep a watchful eye on the emergence of drug resistance.

Updated Gonorrhea Clinical Training:

  • Gonorrhea Self Study Module -- Web-based training course designed to guide clinicians in the diagnosis, treatment, and prevention of gonorrheal infection. Continuing education credits available.
  • Ready to Use Gonorrhea Curriculum for Clinical Educators -- Comprehensive curricular materials that can be downloaded by clinical educators for classroom use. Each module contains a slide presentation, an instructor's guide, a case study, and test questions.

Banners & Graphics -- Promote STD prevention and link to the updated gonorrhea treatment guidelines by placing banners on your website.

Thank you for your commitment to STD prevention.


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