Per the FAQ: http://wiki.winehq.org/FAQ#head-7f5c96516e61609acb0b2de9c0e6e97eadaff31a > If you are getting a complete deadlock and are unable to even use your mouse after running Wine, it's probably not a specific problem with the Wine software. Wine is a user-level process, and shouldn't be able to completely hang the operating system under any circumstances. Instead, Wine is likely exposing a deeper problem with the system, such as a defective hardware driver, a bad memory stick, or overclocking flakiness. > > It's often a graphics driver problem, in which case non-Wine apps might also be affected. If running glxgears also crashes, it's definitely a graphics driver problem. The most common cause is upgrading to a new kernel without also updating the graphics drivers to match. Try reinstalling your graphics drivers. > > If the computer is a laptop and shutting itself off entirely, a likely cause is overheating. Some laptops have problems with cooling to begin with, and the Linux ACPI code controlling fans is known to be buggy. > > If that doesn't help, ask for help on the wine-users forum. Be sure to mention the name of the app, the version of wine, the output of cat /etc/issue , lspci | grep -i vga , and, if you're using the proprietary NVidia drivers, cat /proc/driver/nvidia/version . Maybe someone can help. So, what version of wine do you have, and what kind of video card and driver version?