Thanks for the help. The program file is in my Applications folder. When it installs it seems to unpack it into the Program folder on Drive C (I've installed it twice now as OpenBUGS and OpenBUGS321 (version 3.2.1)). I suspected I didn't have the correct location for the file, and I can't find anything on my machine called OpenBUGs by searching (except in the Applications folder). I am not a programmer (obviously); thanks for the help. I just want to do some Bayesian statistics on my Mac. MMH-MacBook-Pro:OpenBugs MMH$ cd /Applications/OpenBugs MMH-MacBook-Pro:OpenBugs MMH$ wine OpenBUGS.exe fixme:win:DisableProcessWindowsGhosting : stub fixme:msg:ChangeWindowMessageFilter c046 00000001 fixme:msg:ChangeWindowMessageFilter c046 00000001 fixme:msg:ChangeWindowMessageFilter c046 00000001 fixme:shell:SHAutoComplete stub MMH-MacBook-Pro:OpenBugs MMH$ cd ~/.wine/drive_c/Program\ Files/ MMH-MacBook-Pro:Program Files MMH$ ls Common Files Internet Explorer OpenBUGS MMH-MacBook-Pro:Program Files MMH$ ls OpenBUGS OpenBUGS OpenBUGS321 MMHMacBook-Pro:Program Files MMH$ wine OpenBUGS wine: cannot find L"C:\\windows\\system32\\OpenBUGS.exe"