Ok, now things are just getting weird(er). When I right-click the ChemDraw prefix to compress it to save a backup copy, it says "permission denied". If I do it with root, it says "no such directory" or something like that. I install 7zip into WINE, and that could compress it. I delete the old one (got messed up by 1.3.27) and try to put back my backup. When I do: > WINEPREFIX=$HOME/ChemDraw /wine_1.3.26/bin/wine '/home/shjake/ChemDraw/drive_c/Program Files/CambridgeSoft/ChemOffice2010/ChemDraw/ChemDraw.exe' I get: > wine: cannot find '/home/shjake/ChemDraw/drive_c/Program Files/CambridgeSoft/ChemOffice2010/ChemDraw/ChemDraw.exe' I drug the executable into terminal, so it's the right path; no spelling errors. What is going on? [Exclamation] [Question] :( Jake