DDO definitely has a memory leak and its not unique to Wine, it happens in windows too. The biggest, most helpful workaround is that when changing zones, lower the texture detail to very low. You can change it back after you zone. And this only mitigates the problem from minutes to hours. Also, if you change characters, its best to quit and log back in. (The appdb used to have lots of good information and tips but they seem to have gone away recently...)
