I also tried to do : cd ~ rm -Rf .wine [ this was the default x64 bit wine prefix ] WINEARCH=win32 WINEPREFIX=$HOME/.wine winecfg Windows XP In the separator Libraries there were none. tried to launch the setup.exe by doing : cd /tmp/iso wine setup.exe Gave me immediately this error "Setup did not complete successfully. We are sorry for the" Tried also to do : WINEPREFIX=$HOME/.wine wine setup.exe Same thing. Hope it helps you to help me out here. Thanks in advance! Cheers! :)