Then perform I/O backtracing. Run app through terminal. On problematic lockings you should get some NTFS Stream errors / warnings. Get function / procedure name(s) and find out if there is not missing any Cryptographic features. Currently Wine does not support Windows built-in libraries like Crypt32 ( http://msdn.microsoft.com/en-us/library/aa380255(v=vs.85).aspx ) so if you have data-aware DB app, it should rely on File-systems features, so it means issues are in some NTFS 4.x / 5.x streams. Get some terminal output because it is first thing Wine developers needs to be able to even guess about problematic area(s). More info about "File locking" and most likely called LockFileEx() and possibly faulty one - http://en.wikipedia.org/wiki/File_locking
