Ok thanks for the reply Frédéric Delanoy. I've had some success including the info you linked to which specifies that you can't run under multi users. I had to run: export WINEPREFIX=/home/wine Then I had to make sure that directory was owned by me. Then wine created it's files in that directory as soon as I initiated a wine executable. Preferably you'd run winechg at this stage. The main reason why I wanted wine working out of the my home directory was that I have that dir encrypted and don't want the wine folders losing speed in any decryption.