Even with wine-1.3.16, this game (like MANY others) will not run properly, you will experience the "crazy mouse/mouse escape window" issue (Bug#6971), making game unplayable. you must build wine yourself from sources, using the Xinput2 patch to get rid of it but I don't know if apple X11 support Xinput2, perhaps Xquartz will support it. I hope wine dev will soon commit this patch because this bug affect nearly all recent games. (Assassin's creed games, ME games, Bulletstorm, Crysis games, ect...) regards, WineFan62