Hello, Six month later, I found a solution (in french): [1] And the source of this blog (in english): [2] This solution is for *.exe files, but it works also for *.doc, *.xls, etc. files. It is wery easy. Edit the default launch command for wine Code: gksu gedit /usr/share/applications/wine.desktop Change from Code: Exec=cautious-launcher %f wine start /unix onto Code: Exec=wine start /unix %f I hope this will help sombody. -- [1] http://geekdefrance.fr/2010/12/28/autoriser-lexcution-de-fichier-exe-sous-ubuntu-10-10/comment-page-1/#comment-2433 [2] http://stream-recorder.com/forum/blocked-wine-start-unix-problem-opening-exe-t6560.html