According to http://appdb.winehq.org/objectManager.php?sClass=version&iId=20404 , Guitar Pro 6 works fine with wine 1.1.42 and wine 1.2. For me in current git and Gentoo X64 it does not. I reported the following bug : http://bugs.winehq.org/show_bug.cgi?id=25440 , and tested wine 1.1.42 and wine 1.2 to see if there were regressions. I get the same results with these versions and current git. Therefore either I am doing something wrong or the test results are invalid. Meanwhile, I have uploaded some extra debug information, hoping for improvements. I would like to get input from other GP6 users who use Wine. What are your results? If you get something different than me, how did you obtained these. Thanks!