Big thing here. Wine is not coded for multi user support. So each user has to have a copy of the program they want to run with more permissions than they need or it will screw up. At some point someone will put up there hand to do the major recoding job to make wine simpler to wrap in selinux and others to prevent secuirty issues. Wine should not be seen as a long term tool. It a short term tool. Lot of Windows programs by nature are insecure. So have you audited the application. Almost ever case I have found the program people wants from windows does not pass basic rules of secuirty. So even if wine worked you would be breaching secuirty ideals running it.
