I am running Dragon Naturally Speaking Preferred 10 on openSUSE 11.3 with wine version 1.3.5.2010.1026-1.1. It does not run perfectly; however it is serviceable. I started with a fresh wine install and set it up with winetricks, using the following perimeters: corefonts tahoma firefox gecko ie6 - I couldn't get ie7 to install vcrun2008 winxp winver= volnum Then install DNS10 and follow the directions. I had to do a standard installation, when I tried to do a custom install the install failed. If you get it to work don't change anything with wine. Hope this helps