Install allfonts with Winetricks? which Master of Orion? 1 and 2 came in DOS versions and run in DOSBox great.... 3 gets much harder on the hardware.. but it may run ok until huge fleet battles with tons of missles and fighters.. it'll probably turn into a slideshow... and huge maps after awhile you might end up waiting 5 to 10 minutes between turns.... might wanna stick to small maps. There are no-cd hacks for MoO3 if thats the one your trying to run and its legal to use those in the area you live.
