First, I took a guess at what should be in the menu entry. Seemed to take it, so then I copied the menu entry into a terminal session and this is what I got: ohn@john-lynx-II:~$ env WINEPREFIX="/home/john/.wine" wine C:\\windows\\command\\start.exe /Unix "/home/john/.wine/dosdevices/c:/Program Files/Reader/Reader.exe" john@john-lynx-II:~$ err:module:import_dll Library MFC42.DLL (which is needed by L"C:\\Program Files\\Reader\\OR_DAT.dll") not found err:module:import_dll Library OR_DAT.dll (which is needed by L"C:\\Program Files\\Reader\\Reader.exe") not found err:module:import_dll Library MFC42.DLL (which is needed by L"C:\\Program Files\\Reader\\s3d.dll") not found err:module:import_dll Library s3d.dll (which is needed by L"C:\\Program Files\\Reader\\Reader.exe") not found err:module:import_dll Library MFC42.DLL (which is needed by L"C:\\Program Files\\Reader\\Reader.exe") not found err:module:LdrInitializeThunk Main exe initialization for L"C:\\Program Files\\Reader\\Reader.exe" failed, status c0000135 And then it said nothing. I hit control-C to get back to the shell prompt. Now, there is something I don't understand about the command line or there really is a missing MFC42.dll. The OR_DAT.dll and all its friends are in the Reader directory in wine's Program Files directory, and they are also in a folder on my desktop. The desktop files are cataloged in the library tab with the application in the configure wine panels. The only other thing I can think of is that these dlls should be the ones inside the dosdevices/c:/ directory. Thanks for the patience, but I really am at my wit's end.