Try something like this: (from terminal WITHIN your home directory - do not try this while in CDRom directory) wine start /Unix /path/to/install.exe (or wethever the name is) When it asks you for second CD do this: wine eject or wine eject drive-letter: (if you have multiple cdroms) That should eject the CD, simply change it, mount and installation should continue. NOTE: This will probably NOT work if you try this while in directory where cdrom is mounted, every other dir should do just fine.