X-Windows wrote: > Alright, completely removed and reinstalled wine. Starting fresh, here is what I am doing. > > > Code: > > export WINEPREFIX=/media/Wine > cd /media/CD_name > wine Setup.exe > > > > > When I click the launcher button to start an installer (Install Shield) I get the same error as in my first post. When I click the "Browse C: Drive" it correctly takes me to the clean install drive_c. > > With an app that uses a different installer, the program installs without issue, but when I try to run the program, it throws the same error: "<programname> has encountered a serious problem and needs to close". For the InstallShield problem: what version of Wine are you using? If it's not the latest development release, upgrade. There were some problems with InstallShield a few versions ago that have been fixed. For the second problem: what app is this? Post terminal output. Make sure you cd to the program directory before trying to run it. Apps can fail to run for lots of reasons; don't assume this problem has anything to do with the location of the wineprefix.