Does that mean a single prefix for both 32 bit and 64 bit apps? Does it mean a single installation of wine for the same? Well, however it works it's a good idea. I think a lot of 64 bit Windows apps right now are actually 32/64 hybrids that do install some 32 bit stuff too. Especially suites of multiple apps. Tonglebeak of the Gentoo forums asked the same question: http://forums.gentoo.org/viewtopic.php?p=6229606 I just thought we're more likely to get an answer here.