Somehow you lost permissions to write to your own home directory. Start Terminal.app (from Finder: Applications -> Utilities -> Terminal), and fix ownship and perms on the top-level directory by running this
Code:
MYHOME=${HOME}
MYUSER=${USER}
MYGROUP=$(groups | cut -f 1 -d' ')
sudo chown -R ${MYUSER}:${MYGROUP} ${MYHOME}
chmod 755 ${MYHOME}
Then attempt to create and remove a couple of test directories:
Code:
mkdir ~/testdir
mkdir ~/.winetest
rmdir ~/testdir
rmdir ~/.winetest
