This is really frustrating. Its still giving me the error message of the ~/.wine folder not existing. I followed this guys tutorial perfectly and did the Snow Leopard options: http://davidbaumgold.com/tutorials/wine-mac/#part-3 I got no error messages along the way while it was building. Is there anyway to change the root path or prefix or anything like that so the directory will be created? I can't create the directory in my home directory because I don't have permission despite using sudo. I wish this wasn't so troublesome unlike how it was in Ubuntu.