The FAQ and wiki have the best general documentation. There's also a Wine User's Guide, but parts of it are badly outdated. Info in the AppDB varies from excellent to nil, depending on the app. The forum has a lot of good info, too, though you may have to weed through a lot of threads to find what you need. You didn't mention what Wine version you're using; if it's not the latest development release (currently 1.1.39), upgrade. That alone may solve many problems. I really can't give you more help than that without specific information about what app you're trying to run, what problem you're encountering trying to run it, and what part of the documentation you've read that you don't understand.
