I've found most games in OSX that has to use Xquartz X11 does NOT run right at all without using a virtual desktop. This is due to limitations in Xquartz itself.... its decent and getting better, but for Wine gaming, Xquartz really stinks. You might look into making wrappers (or finding some others have made) using Wineskin (http://wineskin.sourceforge.net). I have some work arounds its does for fullscreen gaming... including changing resolutions and such.... that Xquartz cannot even do. Its not perfect, but better than trying just using standard X11.app Xquartz.... plus you end up with just a normal double click to run .app, so it seems very Mac native.
