Ok, i use this command when i installed Mass Effect (iso DVD) and Mass Effect 2 (DVD version) and it works fine. Mass Effect : Code: mount -o loop MEDVD1.iso /media/cdrom wine start /unix /media/cdrom/Setup.exe When the Installation ask me the second DVD : Code: umount /media/cdrom mount -o loop MEDVD2.iso /media/cdrom Which game do you want to install? When the installation ask you to insert the 2nd DVD, have you got a windows with this question?