WinXP is the most tested and is current the default OS for wine. winetricks is only used for applications that don't work correctly. You don't just install a stack of stuff from it and expect applications to work. Most things in winetricks are double sided swords. ie help X application to work and cause Y application to fail. "man wine" Read and understand about WINEPREFIX this is a useful feature to split configurations of wine down to individual programs. More you want to use winetricks the more you need to understand about WINEPREFIX. Most platuim rated applications operation on wine alone without needing anything installed from winetricks. The name winetricks is part a warning. It tricks stuff into working. It also tricks stuff into failing that should not either.