Here is the output of trying to run winword.exe through the terminal Code: gina@gina-laptop ~/.wine/drive_c/Program Files/Microsoft Office/Office12 $ wine winword.exe fixme:actctx:parse_depend_manifests Could not find dependent assembly L"Microsoft.VC80.CRT" (8.0.50608.0) err:module:import_dll Library MSVCR80.dll (which is needed by L"C:\\Program Files\\Microsoft Office\\Office12\\winword.exe") not found err:module:LdrInitializeThunk Main exe initialization for L"C:\\Program Files\\Microsoft Office\\Office12\\winword.exe" failed, status c0000135 Hope this helps...