bug #11112 http://bugs.winehq.org/show_bug.cgi?id=11112 is about running multiple wineservers at the same time. In a common situation of multiple users sharing the same machine, obviously not at the same time, the solution on that howto http://ubuntuforums.org/showthread.php?t=917422 does not seem problematic. Of course, if the users' home are shared over the network, that solution doesn't work even if using the same user account. Personally I prefer to have different wineprefixes per application and per user but keep the program files in a shared location (just using a drive letter to point to it).
