I prefer Macports.. but technically you can run both... though sometimes with multiple versions of the same app in different places, depending on your path and stuff, might have some issues.... the best part of Macports though has to be xorg (which wine needs) ... always keep xorg updated and run X11.app from the /Application/Macports entry it makes... its sooo much better than Apples X11, and always kept up-to-date and can be run on 10.4 - 10.6... if you install xorg from macports and want it to be your system default X11 instead of Apple's, you need to edit the file... "/System/Library/LaunchAgents/org.x.startx.plist" and change this line "/usr/X11/bin/startx" to this "/opt/local/bin/startx" if your macports is default... then anytime Wine or any other X11 using app tries to run, it'll launch the much better xorg version.
