First, a warning that your external drive must not contain an actual Windows installation. The wineprefix (Wine's sandboxed Windows environment) and a real Windows environment are incompatible and would destroy the regular Windows install (as in not bootable). Now, for the steps: - Open a terminal. - Use the "cd" command to go to your application installer's directory. Ex. "cd ~/Downloads" where ~ means /home/your_username/. - Normally, you'd run "wine filename.exe" here. But this time we're changing the wineprefix, so do: Code: WINEPREFIX=/path/to/external/disk/ wine filename.exe You can also do this once: Code: export WINEPREFIX=/path/to/external/disk/ and your current terminal will always use that path for the current terminal session. So you can then install apps with a simple "wine filename.exe" anyway (until you close the terminal, after which you have to set the wineprefix *again*). Also be aware that if your external drive isn't formatted as ext3, some Windows applications might not work. But I myself haven't actually ever encountered this.