Something that makes your Wine installation a lot safer to use is by removing the Z: association to /. Wine can't write to most directories from / anyway, but your other partitions or disks in /media/ will become inaccessible through Wine so the only thing viruses could then do it trash your /home/user. And if you back that up regulary you should be just fine from there on. Do note that you can't run applications from these external drives/partitions if you do this, of course, unless you add direct references in winecfg to the disks you DO want access to in Wine.
