In Fedora 11 the ALSA sound sequencer isn't created at start up (due to migration to UDEV). Solution: Create the file dist-alsa.conf containing: # Make midi applications work on systems with a soundcard: install snd-pcm /sbin/modprobe --ignore-install snd-pcm && /sbin/modprobe snd-seq in /etc/modprobe.d. After system reboot the /dev/snd/seq device should be available.