Looks like it's due to a client update, not Wine. I'm not sure if winetricks has an installer for the right version, or where else you would get it though. Just another great MS way of making sure CLR apps are dependent on Windows, I suppose: evil@mars:~/Public/win/games/Runes of Magic$ wine Runes\ of\ Magic.exe fixme:actctx:parse_assembly_elem wrong version for assembly manifest: 8.0.50608.0 / 8.0.50727.762 fixme:actctx:parse_manifest_buffer failed to parse manifest L"W:\\games\\Runes of Magic\\Microsoft.VC80.CRT\\Microsoft.VC80.CRT.manifest" fixme:actctx:parse_depend_manifests Could not find dependent assembly L"Microsoft.VC80.CRT" (8.0.50608.0) fixme:actctx:parse_assembly_elem wrong version for assembly manifest: 8.0.50608.0 / 8.0.50727.762 fixme:actctx:parse_manifest_buffer failed to parse manifest L"W:\\games\\Runes of Magic\\Microsoft.VC80.CRT\\Microsoft.VC80.CRT.manifest" fixme:actctx:parse_depend_manifests Could not find dependent assembly L"Microsoft.VC80.CRT" (8.0.50608.0) err:module:import_dll Library MSVCR80.dll (which is needed by L"W:\\games\\Runes of Magic\\xerces-c_2_8.dll") not found err:module:import_dll Library xerces-c_2_8.dll (which is needed by L"W:\\games\\Runes of Magic\\Client.exe") not found evil@mars:~/Public/win/games/Runes of Magic$ err:module:LdrInitializeThunk Main exe initialization for L"W:\\games\\Runes of Magic\\Client.exe" failed, status c0000135