Check the AppDB (link at top) for the individual apps you wish to keep. If they are not supported/working at this time, the best option is to find a Linux equivalent. I've found there are very few Windows apps (other than games) that don't have a passable (and free) Linux alternative. After that, you might consider using a VM to run an old version of Windows (we all have a license somewhere). Solutions like VirtualBox allow you to run the Windows apps on the same desktop - side-by side with your Linux apps. This is a great solution for apps that don't run under Wine yet and do not need hardware acceleration. If what you want is to run a game, or use some other finicky piece of hardware that will not work right with Linux, I'd recommend setting up a dual-boot environment until such time as Linux/Wine can fully meet your requirements.
