You do it wrong, you should call different wineprefixes. Eg. WINEPREFIX="$HOME/.wine" wine GomezPEER2.exe WINEPREFIX="$HOME/.wine-gomez2" wine GomezPEER2.exe Where .wine is the default wineprefix and .wine-gomez2 is your second wineprefix. So ".wine" is computer 1 and .wine-gomez2 is computer 2