The http://wiki.winehq.org/WineOn64bit page would give you some clues. There's a Fedora section at the bottom. Also if you don't need Capi support pass --without-capi to ./confgiure like this. ./configure --enable-maintainer-mode --without-capi If you run './configure --help' it'll give you all the options. --disable-tests is also good if you don't want them. With gnutls you might have to pass the CFLAGS / LIBS to configure about where gnutls is. GNUTLS_CFLAGS='whatdirectory' / GNUTLS_LIBS='whatdirectory'. Know what I'm talking about? :)